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Tumor Treating Fields (TTFields) for Glioblastoma: Standardized Use in Shanghai

TTFields deliver low-intensity alternating electric fields to disrupt tumor cell division and have become an important maintenance option for glioblastoma. This article covers eligible patients, wearing requirements, follow-up and the treatment pathway in Shanghai.

November 5, 20261 min readSource: MedBridge Shanghai 编辑部

Glioblastoma (GBM) is the most common malignant brain tumor in adults. Standard care usually includes maximal safe resection, radiotherapy with temozolomide, followed by a maintenance phase. In recent years, Tumor Treating Fields (TTFields) have been increasingly integrated into comprehensive neuro-oncology programs as a maintenance approach.

How it works

TTFields apply low-intensity, intermediate-frequency alternating electric fields through electrode arrays placed on the scalp, interfering with key structures during tumor cell mitosis and thereby suppressing tumor cell proliferation. The treatment is non-invasive and can be used at home; patients need to wear the device for long hours each day as prescribed, change electrode arrays regularly and monitor scalp condition.

Who should be evaluated

Eligibility is judged by neurosurgeons and oncologists together, taking into account molecular pathology, extent of resection, prior treatments and overall condition. Implanted electronic devices such as cardiac pacemakers, scalp wounds or infection, and pregnancy usually require special assessment. Any treatment may involve contraindications; please consult a qualified physician before treatment.

Pathway in Shanghai

1. Submit pathology and imaging for multidisciplinary team (MDT) review at a partner hospital;

2. Build an individualized plan and complete training on device wearing and daily maintenance;

3. Attend scheduled follow-ups to assess adherence, skin reactions and imaging changes;

4. Seek care promptly if headache worsens, seizures occur or neurological function changes.

For cost structure and hospitalization arrangements, see the transparent pricing page, and submit records via online consultation for a preliminary opinion. Any treatment may involve contraindications; please consult a qualified physician first.